KILLER BEE'S FAT BURNER
KILLER BEE'S FAT BURNER

KILLER BEE'S FAT BURNER

Regular price $59.99 Sale

The World's Strongest Fat Burner

  • Powerful Fat Burning Ingredients*
  • Increases Thermogenesis & Resting Metabolic Rate*
  • Decreases Water Retention*
  • Suppresses appetite*
  • Euphoria Complex For Amplified Mental Alertness*
  • 60 Servings Per Container

Body composition, and particularly fat loss, are important for a variety of reasons. They assist in improving athletic performance, overall health, and they improve what’s looking back at you in the mirror! However, we could all use a little help when it comes to fat loss, because we know it’s not easy relying on diet and exercise alone. That is why Hypergenetics Labs is proud to present Killer Bees, a remarkable combination of cutting-edge thermogenic and appetite-suppressing ingredients. The amazing blend of neuroenhancers synergize to provide long-lasting benefits that keep cranking up the dial to make that burn last long!

  • Phenethylamines – N-phenethyldimethylamine, beta-phenylethylamine, and hordenine combine to provide a safe, but noticeable boost in energy, focus, and fat-burning power!
  • Acetyl L-tyrosine and 5-HTP – precursors to serotonin, a neurotransmitter which will help to balance the dopamine boost from the phenethylamines while directly boosting mood and weight loss as well
  • Caffeine and Infinergy – two forms of caffeine provide a one-two punch of fast and slow release
  • Cayenne and Capsiatra – two forms of capsinoids proven to increase metabolic rate and caloric burn while decreasing appetite

The blend of top notch fat loss molecules in this formula work to address fat loss on multiple fronts. Increased caloric burn and decreased appetite are not just handled, but amplified through perfect ingredient synergy. Add in the laser focus and razor-sharp attention, and you have the thermogenic supplement that will optimize your body composition and your workouts: Killer Bees.

N-Phenethyldimethylamine

This monoamine alkaloid is naturally derived from the orchid Eria Jarensis. Chemically similar to 1,3 dimethylamylamine, this legal ingredient provides many of the same benefits, such as increased energy, concentration, focus, and fat burning.

  • Naturally-derived monoamine alkaloids have demonstrated profound appetite suppression, as well as increased metabolism via adrenaline release.

Norcoclaurine

This naturally-occurring stimulant is a beta-2 adrenergic agonist, which reduces fat mass, enhances adrenaline release, the opening of airways, and vasodilation to the muscle. In addition to improving fat loss, focus, and blood flow to the muscles, it also exhibits antioxidant and anti-inflammatory benefits.

  • Nojima et al. (2000) observed that norcoclaurine exhibited improved acetylcholine release in motor neurons, suggesting enhanced muscular contraction.

Cocoa Extract

Cocoa contains both caffeine and theobromine, which has a similar chemical structure to caffeine. Both of these stimulants are known to increase metabolism and burn excess calories. In addition, cocoa is high in antioxidants called flavonols that have been shown to improve cholesterol and other enzymes related to fat metabolism.

  • In a study by Matsui et al. (2005), consumption of cocoa limited the onset of obesity in rats who were fed a high-fat diet through the modulation of expression of genes related to fatty acid metabolism.

White Willow

White willow provides a natural source of salicylic acid, which is the active constituent of aspirin. Not only does it work for pain relief, but it has been stacked with ephedrine and caffeine to activate weight loss. In this formula, it can synergize with caffeine and other natural catecholamine boosters to obtain similar results.

  • Salicylic acid increases the benefits of caffeine and phenethylamines to increase metabolic rate and promote weight loss.

Cayenne Pepper Extract

Cayenne pepper is a potent activator of metabolism. Through its activation of Trp channels in the body, cayenne is able to increase metabolic rate and activate calorie burning at rest, leading to greater weight loss.

  • Urbina et al. (2017) found that cayenne consumption lowered food intake (i.e. appetite suppression) and reduced waist to hip ratio.

Capsiatra

Capsiatra consists of capsiate – a capsinoid found in sweet bell peppers. Though not as hot to taste, capsiate also activated TRP channels and has similar benefits to cayenne pepper.

  • Capsiate increased resting metabolic rate and decreased respiratory quotient (more fat burned than carbohydrate) in a 2016 meta-analysis of human studies.

Caffeine Anhydrous

Caffeine is well known as a stimulant and metabolic enhancer. Not only will caffeine provide enhanced attention and focus, but it will also increase metabolic rate and caloric burn.

  • In a recent review article (2017), caffeine has been shown to increase energy expenditure via thermogenesis, fat oxidation, and to decrease energy intake via decreased appetite, thereby contributing to weight loss on multiple fronts.

Dicaffeine Malate (as Infinergy)

This type of caffeine provides a different metabolic profile to the body. Thourhg its unique chemical structure, it has a slower release rate that caffeine anhydrous, which also means it lasts longer. When paired with caffeine anhydrous, it provides fast and slow release of caffeine to give you sustained energy throughout the day and no crash afterward.

  • Malic acid is a Krebs cycle intermediate which can help with energy availability through ATP production. Ionic bonding of caffeine to malic acid helps to alter the compound’s metabolism and slow the release of caffeine into the blood.

Beta-phenylethylamine HCl

Sometimes known as the “love drug,” this fast-acting chemical is found naturally in the body and affects both mood and energy levels via activation of dopamine and norepinephrine. Its benefits also extend to fat loss since it activates catecholamine release.

  • Paterson (1993) demonstrated how phenylethylamine activated noradrenaline receptors independent of noradrenaline in a sympathomimetic fashion.

5-HTP

While phenethylamines are derived from phenylalanine and are precursors to dopamine, 5-HTP is derived from tyrosine and is a precursor to serotonin – the other major mood neurotransmitter. Additionally, 5-HTP has profound effects on appetite suppression and therefore weight loss.

  • Ceci et al. (1989) found that supplementation with 5-HTP reduced caloric intake by 38%, resulting in weight loss.

Hordenine

Hordenine is another naturally-occurring monoamine that is a beta-adrenergic agonist. As such, it can improve energy, attention, and focus while enhancing weight loss through increased metabolic rate and decreased appetite.

  • First discovered in horses who ate sprouted barley, further animal studies determined that metabolic rate was increased after administration with hordenine.

Acetyl L-Tyrosine

Tyrosine is a precursor to 5-HTP and serotonin, a neurotransmitter that plays a major role in mood and energy. The acetyl group attached to tyrosine helps the molecule cross the blood brain barrier, so that it can be used for neurotransmitter synthesis.

  • Banderet et al. (1989) found that tyrosine induced improvements in mood and cognitive function in military personnel under environmental stress.

Zingerone (from ginger powder)

Ginger has many benefits on the gastrointestinal tract and has been used as a digestive aid for centuries. It can suppress appetite as well as increase the calories burned while digesting food, demonstrating a dual action to increase weight loss.

  • Mansour et al. (2015) demonstrated the ginger consumption resulted in lower hunger, lower food intake and greater fullness, while simultaneously increasing the thermic effect of food, resulting in more calories burned.

Alpha Lipoic Acid

Alpha lipoic acid is a fatty acid with many roles in the body. One such role is its ability to downregulate AMP kinase, which is an important sensor for regulation of food intake. When this molecule is inhibited, food intake is reduced because of appetite suppression.

  • Kim et al. (2004) reported that alpha lipoic acid reduced AMP kinase, causing profound weight loss via reduced food intake and enhanced energy expenditure.

Raspberry Ketones

This ingredient has become a popular weight loss supplement. It ability to enhance fat burning is primarily through activation of lipolytic enzymes, which are molecules that are involved in the process of burning fat.

  • Raspberry ketones tripled glycerol release, an indicator of lipolysis, and increased gene expression of enzymes involved in fat oxidation, such as hormone-sensitive lipase (HSL).

Yohimbine

Yohimbine is a potent fat burner that works primarily through activation of adrenaline release. It also works by activating fat burning directly.

  • Ostojic et al. (2006) reported notable reductions in body fat in soccer players after supplementation with yohimbine.

Chromium Picolinate

Chromium is a trace mineral that is required by humans in micro amounts for optimal functioning. Studies show that it is an effective appetite suppressor and reduces overall caloric intake. 

  • Chromium administration reduced food intake, hunger cravings, and fat cravings in an animal model.

Q: How do I take Killer Bees?

A: Take 1 capsule with water once daily. It is important to assess how your specific body responds, so if feeling unusual after taking, reduce to every other day. Preferably take in on an empty stomach.

Q: What are phenethylamines?

A: Phenethylamines are monamine activators of many neurotransmitters, such as dopamine and serotonin. They also activate catecholamine release, such as adrenaline and noradrenaline. Through these neurotansmitters and hormones, they increase both cognitive function and fat loss.

Q: Is Killer Bees safe?

Yes, Hypergenetic Labs goes above and beyond to test the safety of our products so that every capsule is formulated and manufactured to our specifications for safety, consistency, and efficacy. That being said, every person is an individual and has specific biochemistry that may interact with one or more of the ingredients is a supplement, so it is important to pay attention to any issues that you are having and to reduce your intake of a supplement if necessary.

Q: When should I take Killer Bees?

Because of the stimulants in Killer Bees, it should not be taken within 8 hours of bedtime. The preferred time to take Killer Bees is first thing in the morning on an empty stomach.

N-Phenethyldimethylamine

  1. Kato, M., et al., β-Phenylethylamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D 2 receptor mechanism. European journal of pharmacology, 2001. 418(1): p. 65-71.
  2. Narang, D., et al., Trace amines and their relevance to psychiatry and neurology: a brief overview. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2011. 21(1): p. 73-79.
  3. Paterson, I., The potentiation of cortical neuron responses to noradrenaline by 2-phenylethylamine is independent of endogenous noradrenaline. Neurochemical research, 1993. 18(12): p. 1329-1336.
  4. Shannon, H.E., E.J. Cone, and D. Yousefnejad, Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. J Pharmacol Exp Ther, 1982. 223(1): p. 190-6.
  5. Ono, H., H. Ito, and H. Fukuda, 2-Phenylethylamine and methamphetamine enhance the spinal monosynaptic reflex by releasing noradrenaline from the terminals of descending fibers. The Japanese Journal of Pharmacology, 1991. 55(3): p. 359-366.

Norcoclaurine

  1. Nojima, H., M. Okazaki, and I. Kimura, Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice. J Asian Nat Prod Res, 2000. 2(3): p. 195-203.
  2. Zhang, N., et al., Applications of Higenamine in pharmacology and medicine. J Ethnopharmacol, 2017. 196: p. 242-252.
  3. Liu, W., et al., Effects of higenamine on regulation of ion transport in guinea pig distal colon. Jpn J Pharmacol, 2000. 84(3): p. 244-51.
  4. Kimura, I., et al., Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria. Jpn J Pharmacol, 1994. 66(1): p. 75-80.

Cocoa

  1. Matsui, N., et al., Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism. Nutrition, 2005. 21(5): p. 594-601.
  2. Gu, Y., et al., Inhibition of key digestive enzymes by cocoa extracts and procyanidins. J Agric Food Chem, 2011. 59(10): p. 5305-11.

Cayenne

  1. Urbina, S.L., et al., Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals. Appetite, 2017. 113: p. 264-273.
  2. Calixto, J.B., et al., Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions. Pharmacol Ther, 2005. 106(2): p. 179-208.
  3. Bloomer, R.J., et al., Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study. Lipids Health Dis, 2010. 9: p. 72.
  4. Conway, S.J., TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1. Chem Soc Rev, 2008. 37(8): p. 1530-45.
  5. Deshpande, J., S. Jeyakodi, and V. Juturu, Tolerability of Capsaicinoids from Capsicum Extract in a Beadlet Form: A Pilot Study. J Toxicol, 2016. 2016: p. 6584649.

Capsiatra

  1. Zsiboras, C., et al., Capsaicin and capsiate could be appropriate agents for treatment of obesity: A meta-analysis of human studies. Crit Rev Food Sci Nutr, 2016: p. 1-9.
  2. Ohyama, K., et al., A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. Diabetes, 2016. 65(5): p. 1410-23.
  3. Watanabe, T. and Y. Terada, Food Compounds Activating Thermosensitive TRP Channels in Asian Herbal and Medicinal Foods. J Nutr Sci Vitaminol (Tokyo), 2015. 61 Suppl: p. S86-8.
  4. Yashiro, K., et al., Capsiate supplementation reduces oxidative cost of contraction in exercising mouse skeletal muscle in vivo. PLoS One, 2015. 10(6): p. e0128016.

Caffeine (as caffeine anhydrous and Di-caffeine Malate)

  1. Astrup, A., et al., Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition, 1990. 51(5): p. 759-767.
  2. Anderson, D.E. and M.S. Hickey, Effects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28 degrees C. Med Sci Sports Exerc, 1994. 26(4): p. 453-8.
  3. Harpaz, E., et al., The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol, 2017. 28(1): p. 1-10.
  4. Gurley, B.J., S.C. Steelman, and S.L. Thomas, Multi-ingredient, caffeine-containing dietary supplements: history, safety, and efficacy. Clin Ther, 2015. 37(2): p. 275-301.
  5. Goldstein, E.R., et al., International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr, 2010. 7(1): p. 5.
  6. Spriet, L.L., Caffeine and performance. Int J Sport Nutr, 1995. 5 Suppl: p. S84-99.

Beta phenylehylamine HCl

  1. Astrup, A., L. Breum, and S. Toubro, Pharmacological and clinical studies of ephedrine and other thermogenic agonists. Obes Res, 1995. 3 Suppl 4: p. 537S-540S.
  2. Kato, M., et al., β-Phenylethylamine modulates acetylcholine release in the rat striatum: involvement of a dopamine D 2 receptor mechanism. European journal of pharmacology, 2001. 418(1): p. 65-71.
  3. Shannon, H.E., E.J. Cone, and D. Yousefnejad, Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. J Pharmacol Exp Ther, 1982. 223(1): p. 190-6.
  4. Paterson, I., The potentiation of cortical neuron responses to noradrenaline by 2-phenylethylamine is independent of endogenous noradrenaline. Neurochemical research, 1993. 18(12): p. 1329-1336.

5-HTP

  1. Ceci, F., et al., The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm, 1989. 76(2): p. 109-17.
  2. Cangiano, C., et al., Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr, 1992. 56(5): p. 863-7.
  3. Cangiano, C., et al., Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord, 1998. 22(7): p. 648-54.

Hordenine

  1. Frank, M., et al., Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse. Equine Vet J, 1990. 22(6): p. 437-41.
  2. Hapke, H.J. and W. Strathmann, [Pharmacological effects of hordenine]. Dtsch Tierarztl Wochenschr, 1995. 102(6): p. 228-32.
  3. Pellati, F. and S. Benvenuti, Chromatographic and electrophoretic methods for the analysis of phenethylamine [corrected] alkaloids in Citrus aurantium. J Chromatogr A, 2007. 1161(1-2): p. 71-88.
  4. Servillo, L., et al., Tyramine Pathways in Citrus Plant Defense: Glycoconjugates of Tyramine and Its N-Methylated Derivatives. J Agric Food Chem, 2017. 65(4): p. 892-899.
  5. Konczol, A., et al., Blood-brain barrier specific permeability assay reveals N-methylated tyramine derivatives in standardised leaf extracts and herbal products of Ginkgo biloba. J Pharm Biomed Anal, 2016. 131: p. 167-174.

Tyrosine

  1. Banderet, L.E. and H.R. Lieberman, Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull, 1989. 22(4): p. 759-62.
  2. Deijen, J.B., et al., Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull, 1999. 48(2): p. 203-9.
  3. Neri, D.F., et al., The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med, 1995. 66(4): p. 313-9.
  4. Jung, Y.P., et al., Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditure, cognitive function and exercise performance. J Int Soc Sports Nutr, 2017. 14: p. 3.
  5. Jung, Y.P., et al., Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males. J Int Soc Sports Nutr, 2017. 14: p. 1.

Ginger

  1. Mansour, M.S., et al., Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study. Metabolism, 2012. 61(10): p. 1347-52.
  2. Taghizadeh, M., et al., The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Ann Nutr Metab, 2017. 70(4): p. 277-285.
  3. Ebrahimzadeh Attari, V., et al., Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT. Eur J Nutr, 2016. 55(6): p. 2129-36.
  4. Saravanan, G., et al., Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet. J Sci Food Agric, 2014. 94(14): p. 2972-7.

Alpha Lipoic Acid

  1. Kim, M.S., et al., Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med, 2004. 10(7): p. 727-33.
  2. Namazi, N., B. Larijani, and L. Azadbakht, Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials. Clin Nutr, 2017.
  3. Al-Ghamdi, M.A., et al., Potential Administration of Lipoic Acid and Coenzyme Q against Adipogensis: Target for Weight Reduction. Afr J Tradit Complement Altern Med, 2017. 14(1): p. 272-277.
  4. Kucukgoncu, S., et al., Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obes Rev, 2017. 18(5): p. 594-601.
  5. Li, N., et al., Effects of oral alpha-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf), 2017. 86(5): p. 680-687.

Raspberry Ketones

  1. Park, K.S., Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med, 2010. 76(15): p. 1654-8.
  2. Park, K.S., Raspberry ketone, a naturally occurring phenolic compound, inhibits adipogenic and lipogenic gene expression in 3T3-L1 adipocytes. Pharm Biol, 2015. 53(6): p. 870-5.
  3. Morimoto, C., et al., Anti-obese action of raspberry ketone. Life Sci, 2005. 77(2): p. 194-204.
  4. Wang, L., X. Meng, and F. Zhang, Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food, 2012. 15(5): p. 495-503.

Yohimbine

  1. Alkhatib, A., et al., Acute effectiveness of a "fat-loss" product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise. J Int Soc Sports Nutr, 2015. 12: p. 44.
  2. Ostojic, S.M., Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med, 2006. 14(4): p. 289-99.
  3. Bahmani, M., et al., Obesity Phytotherapy: Review of Native Herbs Used in Traditional Medicine for Obesity. J Evid Based Complementary Altern Med, 2016. 21(3): p. 228-34.

Chromium

  1. Cefalu, W.T., et al., Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus. Metabolism, 2010. 59(5): p. 755-62.
  2. Anton, S.D., et al., Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther, 2008. 10(5): p. 405-12.
  3. Docherty, J.P., et al., A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. J Psychiatr Pract, 2005. 11(5): p. 302-14.